the Carson campaign's campaign manager, communications manager, and about 18 other staffers had resigned sounds like a pretty big deal.
I'm not sure how this will affect the campaign because this is a damn weird campaign. I've pointed out that he isn't a traditional or particularly experienced candidate, and his campaign looks like it mostly exists to fundraise, not to actually get the candidate elected. The campaign has pretty bad media-discipline, which was particularly apparent when an actual story featuring Carson's foreign policy advisors indicated that he did not really know what he was talking about where foreign policy was concerned.
One of those advisors, Maj. Gen Robert Dees, is now Carson's campaign manager. That seems awkward.
But the whole campaign is awkward--take for example the fundraising. Carson raised $23 million this quarter, topping Ted Cruz's quite respectable $20 million. This is despite poll numbers that have collapsed the last two months. And yet the campaign chugs on, while the candidate maintains a book tour and paid speech schedule.